AGA Research Forum – Neuroimaging and brain-gut interactions
RDX5791, a first-in-class minimally systemic NHE3 inhibitor in clinical development for CIC and IBS-C, increases intestinal sodium leading to enhanced intestinal fluid volume and transit , Andrew G. Spencer, Michael R. Leadbetter, Eric D. Labonte, Chris Carreras, Samantha Koo-McCoy, Marc Navre, Jeffrey W. Jacobs, Xunxiang Du, Noah Bell, Jill Kohler, David Rosenbaum, Dominique Charmot
AGA topic forum – Integrative physiology and pharmacology of the gut
Visceral antinociceptive effects of RDX5791, a potent NHE3 inhibitor on stress-induced colorectal hypersensitivity to distension in rats Hélène Eutamène, Marc Navre, Dominique Charmot, L. Bueno
Departement of Neurogastroenterology INRA,Toulouse, france
Ardelyx Inc. 34175 Ardenwood Blvd, Fremont, CA 94555, USA
